Microbiological and chemical dehydrogenation of withaferin A |
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| Authors: | J Fuska B Proksa J Williamson J P Rosazza |
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| Institution: | (1) Department of Biochemical Technology, Faculty of Chemical Technology, Slovak Polytechnical University, 812 37 Bratislava, Czechoslovakia;(2) Institute of Chemistry, Slovak Academy of Sciences, 842 20 Bratislava, Czechoslovakia;(3) Division of Medicinal Chemistry and Natural Products, College of Pharmacy, University of Iowa, 52242 Iowa City, Iowa, USA |
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| Abstract: | Arthrobacter simplex dehydrogenated withaferin A to 4-dehydrowithaferin A but it was not able to dehydrogenate this substrate in position 27.
27-Dehydrowithaferin A was prepared chemically using pyridinium chlorochromate. Whereas 4-dehydrowithaferin A surpassed in
its effect on leukemic P388 cells the original compound and all its dérivates synthesized so far, 27-dehydrowithaferin A was
biologically inactive. |
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