Comparison of neoeriocitrin and naringin on proliferation and osteogenic differentiation in MC3T3-E1 |
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Authors: | Lina Li Zhen ZengGuoping Cai |
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Institution: | a Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing, 10084, PR China b Life Science Division, Graduate School at Shenzhen, Tsinghua University, Shenzhen, 518055, PR China c Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, USA |
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Abstract: | Naringin is considered the main effective compound of Drynaria Rhizome, which is used commonly in the treatment of osteoporosis in traditional Chinese medicine. However, we found neoeriocitrin, a new compound isolated from Drynaria Rhizome, showed a better activity than naringin on proliferation and osteogenic differentiation in MC3T3-E1. Both neoeriocitrin and naringin exhibited the best effect on proliferation and osteogenic differentiation at concentration of 2 μg/ml. Neoeriocitrin more significantly improved proliferation and alkaline phosphatase (ALP) activity as well as up-regulated Runx2, COLI and OCN expression by 56%, 37% and 14% respectively than naringin. Furthermore, neoeriocitrin could rescue the inhibition effect of cell differentiation induced by PD98059 to some degree. Therefore, neoeriocitrin may be a new promising candidate drug for treatment of osteoporosis. |
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