Studies of interactions between platinum(II) complexes and some biologically relevant molecules |
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| Authors: | Petrović Dejan Stojimirović Biljana Petrović Biljana Bugarcić Zorica M Bugarcić Zivadin D |
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| Affiliation: | 1. University of Kragujevac, Faculty of Medicine, S. Markovića 69, 34000 Kragujevac, Serbia;2. University of Belgrade, Faculty of Medicine, Dr. Subotića 8, 11000 Beograd, Serbia;3. University of Kragujevac, Faculty of Science, R. Domanovića 12, PO Box 60, 34000 Kragujevac, Serbia and Montenegro |
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| Abstract: | ![]()
The reactions of Pt(II) complexes, cis-[Pt(NH3)2Cl2], [Pt(terpy)Cl]+, [Pt(terpy)(S-cys)]2+, and [Pt(terpy)(N7-guo)]2+, where terpy=2,2':6',2'-terpyridine, S-cys=L-cysteine, and N7-guo=guanosine, with some biologically relevant ligands such as guanosine-5'-monophosphate (5'-GMP), L-cysteine, glutathione (GSH) and some strong sulfur-containing nucleophiles such as diethyldithiocarbamate (dedtc), thiosulfate (sts), and thiourea (tu), were studied in aqueous 0.1 M Hepes at pH of 7.4 using UV-vis, stopped-flow spectrophotometry, and 1H NMR spectroscopy. |
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