Na<sup>+</sup>-dependent,potential-sensitive <span class="small-caps">l</span>-ascorbate transport across brush border membrane vesicles from kidney cortex期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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Na⁺-dependent,potential-sensitive l-ascorbate transport across brush border membrane vesicles from kidney cortex

Authors:	Gerhard Toggenburger Max H?sermann Beat Mütsch Giulio Genoni Markus Kessler Fritz Weber Dietrich Hornig Brigitte O&#x;Neill Giorgio Semenza

Institution:	1. Laboratorium für Biochemie der E.T.H., Universitätstrasse 16, CH 8 092 Zürich, Switzerland;2. Department of Vitamin and Nutrition Research, F. Hoffmann-La Roche & Co., Ltd., Grenzacherstrasse 124, CH 4 002 Basle Switzerland

Abstract:	l-Ascorbate is taken up into brush border vesicles from kidney cortex of rat, rabbit and guinea pig by an efficient, Na⁺-dependent and potential-sensitive transport process. This uptake shows saturation ( $K_{m:0.1–0.3 mM}$ ) and is strongly stimulated by low concentrations of N₃^?. Erythorbate (d-isoascorbate) seems to be another, but poorer, substrate of the same transporter.

Keywords:	Potential dependence (Kidney cortex) DTT dithiothreitol FCCP Hepes Mes To whom correspondence and requests for reprints should be addressed
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