Lack of Candida africana and Candida dubliniensis in vaginal Candida albicans isolates in Turkey using HWP1 gene polymorphisms |
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| Authors: | Gumral Ramazan Sancak Banu Guzel Ahmet Bar?? Saraçl? Mehmet Ali Ilkit Macit |
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| Institution: | (1) Department of Microbiology, Gulhane Military Medical Academy, Ankara, Turkey;(2) Department of Microbiology, Faculty of Medicine, University of Hacettepe, Ankara, Turkey;(3) Department of Obstetrics and Gynecology, Faculty of Medicine, University of ?ukurova, Adana, Turkey;(4) Division of Mycology, Department of Microbiology, Faculty of Medicine, University of ?ukurova, 01330 Adana, Turkey; |
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| Abstract: | Candida africana differs from the common strains of C. albicans and C. dubliniensis morphologically, physiologically, genetically, and, in particular, clinically. This fungal pathogen is primarily recovered
from genital specimens, especially in vaginal specimens. In this investigation, we reexamined 195 vaginal C. albicans isolates for the presence of C. africana and C. dubliniensis by using hyphal wall protein 1 (HWP1) gene polymorphisms. All study isolates were confirmed to be C. albicans, and none were verified as either C. africana or C. dubliniensis. In conclusion, the HWP1 gene polymorphisms offer a useful tool in the discrimination of C. africana, C. albicans, and C. dubliniensis. Further studies may highlight the pathogenesis and importance of this yeast in vulvovaginal candidiasis. |
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