Lactate dehydrogenase isoenzyme 1 (LDH-1) in athymic mice with xenografts of a human testicular germ cell tumor |
| |
| Authors: | Finn E von Eyben Gunnar Skude Claes Tropé Johan Wennerberg and Pawel Mikulowski |
| |
| Institution: | (1) Department of Oncology and Radiotherapy, Malmö General Hospital, Malmo, Sweden;(2) Department of Clinical Chemistry, Central Hospital, Kalmar, Sweden;(3) Department of Oncology, University of Lund, Lund, Sweden;(4) Department of Otorhinolaryngology, University of Lund, Lund, Sweden;(5) Department of Pathology, Malmö General Hospital, Sweden |
| |
| Abstract: | Summary Lactate dehydrogenase (LDH) and LDH isoenzyme activities were determined in tumor tissue, tumor cystic fluid, and serum from athymic mice with transplants of a human testicular germ cell tumor. High activity of LDH-1 was found in tumor tissue and tumor cystic fluid. By histochemical staining LDH was found in all tumor cells. Most tumor cells had a faint staining reaction while some cells dispersed throughout the tumor had a strong staining reaction. The serum LDH-1 in athymic mice with tumor transplants correlated markedly with the tumor volume. The results indicate that serum LDH-1 was derived from the testicular germ cell tumor transplants. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
