Localization of the murine macrophage colony-stimulating factor gene to chromosome 3 using interspecific backcross analysis |
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| Authors: | A M Buchberg N A Jenkins N G Copeland |
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| Institution: | Mammalian Genetics Laboratory, NCI-Frederick Cancer Research Facility, Maryland 21701. |
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| Abstract: | The chromosomal location of the murine macrophage colony-stimulating factor (Csfm) gene was determined by interspecific backcross analysis. We mapped Csfm to mouse chromosome 3, 2.5 cM distal to Ngfb and Nras and 1.3 cM proximal to Amy-2. CSFM maps to human chromosome 5q, while AMY2, NGFB, and NRAS map to human chromosome 1p. The chromosomal location of Csfm thus disrupts a previously identified conserved linkage group between mouse chromosome 3 and human chromosome 1. The location of Csfm also identifies yet another mouse chromosome that shares synteny with human chromosome 5q, a region involved in several different types of myeloid disease. |
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