Proteins recruited by SH3 domains of Ruk/CIN85 adaptor identified by LC-MS/MS |
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| Authors: | Serhiy Havrylov Yuriy Rzhepetskyy Agata Malinowska Lyudmyla Drobot Maria Jolanta Redowicz |
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| Affiliation: | (1) Laboratory of Molecular Basis of Cell Motility, Nencki Institute of Experimental Biology, 3 Pasteur str., 02-093 Warsaw, Poland;(2) Laboratory of Mass Spectrometry, Institute of Biochemistry and Biophysics, 5a Pawinskiego str., 02-106 Warsaw, Poland;(3) Palladin Institute of Biochemistry, 9 Leontovich str., Kyiv, 01601, Ukraine |
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| Abstract: | Background Ruk/CIN85 is a mammalian adaptor molecule with three SH3 domains. Using its SH3 domains Ruk/CIN85 can cluster multiple proteins and protein complexes, and, consequently, facilitates organisation of elaborate protein interaction networks with diverse regulatory roles. Previous research linked Ruk/CIN85 with the regulation of vesicle-mediated transport and cancer cell invasiveness. Despite the recent findings, precise molecular functions of Ruk/CIN85 in these processes remain largely elusive and further research is hampered by a lack of complete lists of its partner proteins. |
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