B cells in autoimmunity |
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Authors: | Thomas Dörner Annett M Jacobi Peter E Lipsky |
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Institution: | (1) Charite Center 12 and 14, Charite University Hospital and DRFZ Berlin, Chariteplatz 01, 10098 Berlin, Germany;(2) National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892-1560, USA |
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Abstract: | B-cell development is tightly regulated, including the induction of B-cell memory and antibody-secreting plasmablasts and
plasma cells. In the last decade, we have expanded our understanding of effector functions of B cells as well as their roles
in human autoimmune diseases. The current review addresses the role of certain stages of B-cell development as well as plasmablasts/plasma
cells in immune regulation under normal and autoimmune conditions with particular emphasis on systemic lupus erythematosus.
Based on preclinical and clinical data, B cells have emerged increasingly as both effector cells as well as cells with immunoregulatory
potential. |
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Keywords: | |
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