Increased 5-Hydroxytryptamine and Norepinephrine Release from Rat Brain Slices by the Red Sea Flatfish |
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Authors: | Toxin Pardaxin Hoau Yan Wang Eitan Friedman |
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Institution: | New York University School of Medicine, New York, New York, U.S.A. |
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Abstract: | The effect of the Red Sea flatfish toxin pardaxin was examined on K+-evoked and on basal release of either 3H]norepinephrine or 3H]5-hydroxytryptamine from preloaded rat cortical slices. The K+-induced release of the neurotransmitters was stimulated in a dose-related manner at concentrations ranging from 0.5 to 4 micrograms/ml. Basal release of the two transmitters was elevated to a lesser extent. Although the stimulation of evoked release was approximately equivalent for the two neurotransmitters, the response to 5-hydroxytryptamine was reversible whereas that of norepinephrine was not washed by 20 min of superfusion. The mechanisms involved in producing these actions of pardaxin are not known; however, they may be mediated by changes in electrolyte fluxes across the neuronal membranes. |
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Keywords: | Pardaxin a Red Sea flatfish toxin Norepinephrine and 5-hydroxytryptamine release |
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