Inhibitory effect of dietary carotenoids on dinitrofluorobenzene-induced contact hypersensitivity in mice |
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| Authors: | Sakai Shota Sugawara Tatsuya Hirata Takashi |
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| Affiliation: | Division of Applied Biosciences, Graduate School of Agriculture, Kyoto University, Kyoto, Japan. |
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| Abstract: | We evaluated the effect of carotenoids on the dinitrofluorobenzene (DNFB)-induced contact hypersensitivity in mice. Dietary carotenoids significantly inhibited ear swelling and reduced the contents of TNF-α and histamine in the DNFB-treated mice. Our results suggest that dietary carotenoids exerted an anti-inflammatory effect by suppressing mast cell degranulation in vivo. |
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