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Discovery of thiophene-2-carboxylic acids as potent inhibitors of HCV NS5B polymerase and HCV subgenomic RNA replication. Part 1: Sulfonamides |
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| Authors: | Chan Laval Das Sanjoy K Reddy T Jagadeeswar Poisson Carl Proulx Mélanie Pereira Oswy Courchesne Marc Roy Caroline Wang Wuyi Siddiqui Arshad Yannopoulos Constantin G Nguyen-Ba Nghe Labrecque Denis Bethell Richard Hamel Martine Courtemanche-Asselin Philippe L'Heureux Lucille David Maud Nicolas Olivier Brunette Stéphanie Bilimoria Darius Bédard Jean |
| Affiliation: | Shire BioChem Inc., 275 Armand-Frappier, Laval, Quebec, Canada H7V 4A7. lchan@ca.shire.com |
| Abstract: | The discovery of a novel class of HCV NS5B polymerase inhibitors, 3-arylsulfonylamino-5-phenyl-thiophene-2-carboxylic acids is described. SAR studies have yielded several potent inhibitors of HCV polymerase as well as of HCV subgenomic RNA replication in Huh-7 cells. |
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