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Pan-protective anti-alphavirus human antibodies target a conserved E1 protein epitope
Institution:1. Department of Medicine, Washington University School of Medicine, Saint Louis, MO 63110, USA;2. Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63110, USA;3. Department of Molecular Microbiology, Washington University School of Medicine, Saint Louis, MO 63110, USA;4. Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, Saint Louis, MO 63110, USA;5. Andrew M. and Jane M. Bursky Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, Saint Louis, MO 63110, USA;6. Center for Vaccine Research and Department of Immunology, University of Pittsburgh, Pittsburgh, PA 15261, USA;7. Department of Chemistry, Washington University in St. Louis, Saint Louis, MO 63130, USA;8. Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA;9. Integral Molecular, Inc., Philadelphia, PA 19104, USA;10. Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA;11. Vanderbilt Vaccine Center and Departments of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA;12. Emergent BioSolutions, Gaithersburg, MD 20879, USA;13. Department of Internal Medicine II, University Hospital Regensburg, Regensburg, Germany
Abstract:
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  • Keywords:alphavirus  antibody  protection  immunity  Fc effector  inhiibtion  pathogenesis  mice  encephalitis  arthritis
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