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Differential pre-malignant programs and microenvironment chart distinct paths to malignancy in human colorectal polyps
Institution:1. Program in Chemical and Physical Biology, Vanderbilt University School of Medicine, Nashville, TN, USA;2. Epithelial Biology Center, Vanderbilt University Medical Center, Nashville, TN, USA;3. Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN, USA;4. Department of Biostatistics and Center for Quantitative Sciences, Vanderbilt University Medical Center, Nashville, TN, USA;5. Vanderbilt-Ingram Cancer Center, Nashville, TN, USA;6. Department of Medicine, Division of Epidemiology, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, Nashville, TN, USA;7. Department of Medicine, Division of Gastroenterology, Hepatology and Nutrition, Vanderbilt University Medical Center, Nashville, TN, USA;8. Department of Veterans Affairs, Tennessee Valley Healthcare System, Nashville, TN, USA;9. Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA;10. Department of Medicine, Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MD, USA;11. Vanderbilt Technologies for Advanced Genomics, Vanderbilt University Medical Center, Nashville, TN, USA;12. Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA;13. Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA;14. Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA;15. Department of Pathology, Massachusetts General Hospital, Boston, MA, USA;16. Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA;17. Department of Surgery, Massachusetts General Hospital, Boston, MA, USA;18. Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women’s Hospital, Boston, MA, USA;19. Howard Hughes Medical Institute and Koch Institute for Integrative Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA;20. Department of Immunology, Harvard Medical School, Boston, MA, USA;21. Department of Organoid Medicine, Keio University School of Medicine, Tokyo, Japan;22. Clinical Research Division, Fred Hutchinson Cancer Research Center, and Gastroenterology Division, University of Washington School of Medicine, Seattle, WA, USA;23. Department of Surgery, Vanderbilt University Medical Center, Nashville, TN, USA
Abstract:
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  • Keywords:polyp  adenoma  serrated  colorectal cancer  single-cell RNA-seq  multiplex  stem cells  metaplasia  cytotoxic  differentiation
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