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An NK-like CAR T cell transition in CAR T cell dysfunction
Institution:1. Department of Cell and Developmental Biology, Penn Institute of Epigenetics, Perelman School of Medicine, Philadelphia, PA 19104, USA;2. Center for Cellular Immunotherapies, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA;3. Department of Microbiology and Immunology, University of California San Francisco and the Parker Institute for Cancer Immunotherapy at the University of California San Francisco, San Francisco, California 94143, USA;4. Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA;5. Parker Institute for Cancer Immunotherapy at University of Pennsylvania, Philadelphia, PA 19104, USA;6. Department of Microbiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA;7. Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA 19104, USA;8. Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, University of Pennsylvania, Philadelphia, PA 19104, USA;9. Division of Pulmonary, Allergy, and Critical Care, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA;10. Lymphoma Program, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA 19104, USA
Abstract:
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  • Keywords:CAR T cell  pancreatic cancer  T cell dysfunction  immunotherapy  T cell exhaustion  single-cell RNA-seq  immunology  NK-like T cell  cancer  cell transfer therapy  ID3  SOX4
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