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Stem-like intestinal Th17 cells give rise to pathogenic effector T cells during autoimmunity
Institution:1. Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women’s Hospital, Boston, MA 02115, USA;2. Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA;3. Department of Data Science, Dana-Farber Cancer Institute, Boston, MA 02215, USA;4. Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA;5. Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA;6. German Cancer Research Center, DKFZ, Heidelberg 69120, Germany
Abstract:
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  • Keywords:Th17 cells  gut-brain axis  CNS inflammation  multiple sclerosis  stem-like T cells  fate-mapping  autoimmunity  IL-17  GM-CSF  IFNγ
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