B-Cell Control of Regulatory T Cells in Friend Virus Infection |
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| Institution: | 1. Institute of Structural Biology, University of Bonn, 53127 Bonn, Germany;2. Physical and Synthetic Biology, Faculty of Biology, Ludwig-Maximilians-Universität München, 82152 Planegg-Martinsried, Germany;3. Molecular Microscopy Research Group, Zernike Institute for Advanced Materials, University of Groningen, Nijenborgh 4, 9747 AG Groningen, The Netherlands;4. Department of Biology (Area 10), University of York, York YO10 5YW, UK;1. Goodman Cancer Research Centre, McGill University, 1160 Pine Avenue West, Montreal, Québec H3A 1A3, Canada;2. Departments of Biochemistry, McGill University, 1160 Pine Avenue West, Montreal, Québec H3A 1A3, Canada;3. Medicine, McGill University, 1160 Pine Avenue West, Montreal, Québec H3A 1A3, Canada;4. Oncology, McGill University, 1160 Pine Avenue West, Montreal, Québec H3A 1A3, Canada;5. Department of Biology, Faculté des sciences, Université de Sherbrooke, Sherbrooke, Québec J1K 2R1, Canada;6. Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke, Faculté de médecine et des sciences de la santé, Université de Sherbrooke, Sherbrooke, Québec J1K 2R1, Canada;1. Department of Cell Biology, Microbiology and Molecular Biology, University of South Florida, 4202 E. Fowler Ave., Tampa, FL 33620, USA;2. Physics and Materials Science Research Unit, University of Luxembourg, L-1511 Luxembourg, Luxembourg;3. Department of Physics, University of South Florida, 4202 E. Fowler Ave., Tampa, FL 33620, USA;1. Division of Biomedical Convergence, College of Biomedical Science, Kangwon National University, Chuncheon 24341, Republic of Korea;2. Institute of Bioscience and Biotechnology, Kangwon National University, Chuncheon 24341, Republic of Korea;3. College of Veterinary Medicine, Kangwon National University, Chuncheon 24341, Republic of Korea;1. BioBank, The First Affiliated Hospital of Xi''an Jiaotong University, Shaanxi 710061, China;2. Department of Life Sciences, Faculty of Natural Sciences, Imperial College London, SW7 2AZ London, United Kingdom;3. Instrument Analysis Center of Xi''an Jiaotong University, Xi''an, Shaanxi 710049, China;4. School of Pharmacy, Xi''an Jiaotong University, Xi''an 710061, China;5. National Facility for Protein Science, Shanghai Advanced Research Institute, Chinese Academy of Sciences, Shanghai 201210, China |
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| Abstract: | B lymphocytes have well-established effector roles during viral infections, including production of antibodies and functioning as antigen-presenting cells for CD4 + and CD8 + T cells. B cells have also been shown to regulate immune responses and induce regulatory T cells (Tregs). In the Friend virus (FV) model, Tregs are known to inhibit effector CD8 + T-cell responses and contribute to virus persistence. Recent work has uncovered a role for B cells in the induction and activation of Tregs during FV infection. In addition to inducing Tregs, B cell antibody production and antigen-presenting cell activity is a target of Treg suppression. This review focuses on the dynamic interactions between B cells and Tregs during FV infection. |
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