Dissimilar effects of transglutaminase inhibitors on peptide hormone-indiced secretion from testis and pituitary |
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Authors: | W H Moger M Wilkinson |
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Institution: | Departments of Physiology and Biophysics, and Obstetrics and Gynecology, Dalhousie University, Halifax, Nova Scotia, Canada, B3H 4H7 |
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Abstract: | Inhibitors of transglutaminase (monodansylcadaverine and bacitracin) reduced luteinizing hormone stimulated androgen and adenosine - 3′: 5′ - monophosphate production by testicular tissue but had no inhibitory effect on gonadotropin releasing hormone-stimulated luteinizing hormone secretion by the pituitary. These results indicate that there are differences in the mechanisms by which these polypeptide hormones stimulate hormone secretion and suggest a role for protein cross-linking in the mechanism of luteinizing hormone action in the testis. |
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