The Fat-1 Mouse has Brain Docosahexaenoic Acid Levels Achievable Through Fish Oil Feeding |
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| Authors: | Sarah K Orr Jasmin Y M Tong Jing X Kang David W L Ma Richard P Bazinet |
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| Institution: | (1) Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, ON, Canada;(2) Department of Medicine, Harvard Medical School, Boston, MA, USA;(3) Department of Human Health and Nutritional Sciences, College of Biological Science, University of Guelph, Animal Science/Nutrition Building, Rm 342, Guelph, Ontario, N1G 2W1, Canada; |
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| Abstract: | Fat-1 transgenic mice endogenously convert n-6 to n-3 polyunsaturated fatty acids (PUFA). The aims of this study were to test
whether a) fish oil feeding can attain similar brain n-3 PUFA levels as the fat-1 mouse, and b) fat-1 mouse brain docosahexaenoic
acid (22:6n-3; DHA) levels can be potentiated by fish oil feeding. Fat-1 mice and their wildtype littermates consumed either
a 10% safflower oil (SO) or a 2% fish oil and 8% safflower oil chow (FO). Brain total lipid and phospholipid fraction fatty
acids were analyzed using GC-FID. Wildtype mice fed FO chow had similar brain levels of DHA as fat-1 mice fed SO chow. Fat-1
mice fed FO chow had similar brain n-3 PUFA levels as fat-1 mice fed SO chow. In conclusion, brain levels of DHA in the fat-1
mouse can be obtained by and were not further augmented with fish oil feeding. |
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