| MMP-2、MMP-7在卵巢癌中的表达及其临床意义 |
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| 引用本文： | 俞岚,汪万英,甘怀勇,武世伍,宋文庆,郭冰沁.MMP-2、MMP-7在卵巢癌中的表达及其临床意义[J].中国组织化学与细胞化学杂志,2011,20(4):325-330. |
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| 作者姓名： | 俞岚 汪万英 甘怀勇 武世伍 宋文庆 郭冰沁 |
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| 作者单位： | 1. 蚌埠医学院第一附属医院病理科,蚌埠医学院病理学教研室,安徽省感染与免疫重点实验室,安徽,233030
2. 蚌埠医学院第一附属医院中心实验室,安徽,233004 |
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| 基金项目： | 安徽省科技厅研究项目，蚌埠医学院科研项目 |
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| 摘 要： | 目的 探讨MMP-2、MMP-7的表达与卵巢癌临床病理生物学行为的关系以及对患者预后的影响.方法 应用核酸原位杂交和免疫组化对97例卵巢上皮性癌和23例卵巢上皮性良性肿瘤组织进行MMP-2、MMP-7mRNA及蛋白的检测.结果 MMP-2、MMP-7 mRNA及蛋白的表达阳性率在卵巢癌组均显著高于良性肿瘤组(P<0.05).多因素分析,PTNM分期、MMP-2及MMP-7的表达是影响卵巢癌根治术后患者预后的独立因素(P<0.05);MMP-2阳性组与阴性组5年生存率分别为30.6%和76.0%,MMP-7阳性组与阴性组5年生存率分别为19.7%和80.6%,差异均有统计学意义(P<0.05).结论 MMP-2、MMP-7的过表达促进卵巢癌的浸润和转移,联合检测MMP-2和MMP-7可能作为预测和评价患者预后的生物学指标.
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| 关 键 词： | 卵巢癌 基质金属蛋白酶 免疫组织化学 核酸原位杂交 |
Expression and clinical significance of MMP-2 and MMP-7 in ovarian carcinoma |
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| Yu Lan,Wang Wanying,Gan Huaiyong,Wu Shiwu,Song Wenqing,Guo Bingqin.Expression and clinical significance of MMP-2 and MMP-7 in ovarian carcinoma[J].Chinese Journal of Histochemistry and Cytochemistry,2011,20(4):325-330. |
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| Authors: | Yu Lan Wang Wanying Gan Huaiyong Wu Shiwu Song Wenqing Guo Bingqin |
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| Institution: | Yu Lan1,Wang Wanying2,Gan Huaiyong1,Wu Shiwu1,Song Wenqing1,Guo Bingqin1*(1Department of Pathology,The First Affiliated Hospital of Bengbu Medical Collge,Bengbu Medical College,Anhui Key Laboratory of Infection and Immunology,Anhui 233030,2Central Laboratory,Affiliated Hospital of Bengbu Medical College,Anhui 233004,China) |
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| Abstract: | Objective To study the association of the expression of MMP-2 and MMP-7 with the clinicobiologic behavior and prognosis of ovarian carcinoma.Methods In situ hybridization and immunohistochemical staining were used to detect the expression of MMP-2 and MMP-7 in 97 cases of epithelial ovarian cancers and 23 cases of benign epithelial ovarian tumors.Results The positive expressions of MMP-2 and MMP-7 mRNA and protein in ovarian carcinoma were higher than those in benign tumors of the ovary,and there were signi... |
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| Keywords: | Ovarian carcinoma Matrix metalloproteinase Immunohistochemistry Hybridization in situ |
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