| 非小细胞肺癌中血管生成拟态和VEGF的表达及意义 |
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| 引用本文： | 承泽农,武世伍,俞岚,宋文庆,陶仪声.非小细胞肺癌中血管生成拟态和VEGF的表达及意义[J].中国组织化学与细胞化学杂志,2011,20(4):343-348. |
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| 作者姓名： | 承泽农 武世伍 俞岚 宋文庆 陶仪声 |
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| 作者单位： | 蚌埠医学院第一附属医院病理科,蚌埠医学院病理学教研室,安徽,233003 |
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| 摘 要： | 目的探讨血管生成拟态(vasculogenic mimicry,VM)与血管内皮生长因子(vascular epithelial growth factor,VEGF)在非小细胞肺癌(non-small cell lung cancer,NSCLC)中的表达及意义。方法收集NSCLC术后标本160例和20例正常肺组织,应用免疫组化法和组织化学法检测NSCLC和正常肺组织中VM和VEGF的表达情况。结果在NSCLC组织和正常肺组织中,VM和VEGF的阳性率分别为36.9%、51.3%和0%、0%,差异有统计学意义;含有VM的NSCLC的VEGF表达高于无VM者(P<0.05),且VM与NSCLC的组织学分级、淋巴结转移及临床分期等有关(P<0.05);多因素分析:PTNM分期、VM、VEGF的表达是影响NSCLC根治术后患者预后的独立因素(P<0.05);VM阳性组与阴性组的5年生存率分别为1.7%和41.6%,差异有统计学意义;VEGF阳性组与阴性组的5年生存率分别为2.4%和52.6%,差异有统计学意义。结论具有VM的NSCLC组织分化低,患者临床预后差;VEGF的表达水平和VM与NSCLC的发展及预后有一定的关系。
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| 关 键 词： | 非小细胞肺癌 血管生成拟态 血管内皮生长因子 预后 |
The significance of vasculogenic mimicry and VEGF expression in non-small cell lung cancer |
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| Cheng Zenong,Wu Shiwu,Yu Lan,Song Wenqing,Tao Yisheng.The significance of vasculogenic mimicry and VEGF expression in non-small cell lung cancer[J].Chinese Journal of Histochemistry and Cytochemistry,2011,20(4):343-348. |
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| Authors: | Cheng Zenong Wu Shiwu Yu Lan Song Wenqing Tao Yisheng |
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| Institution: | Cheng Zenong,Wu Shiwu,Yu Lan,Song Wenqing,Tao Yisheng*(Department of Pathology,Bengbu Medical College,The First Affiliated Hospital of Bengbu Medical College,Anhui 233003,China) |
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| Abstract: | Objective To explore whether vasculogenic mimicry(VM) exists in non-small cell lung cancer(NSCLC) or not and to elucidate the relationship between VM and the expression of VEGF.Methods The expression of VEGF and VM in 160 specimens of NSCLC and 20 specimens of normal lung tissue were detected by immunohistochemical and histochemical staining.Results The positive rates of VM and VEGF protein in NSCLC were 36.9% and 51.3%,respectively,but 0% and 0% in normal lung tissue.The difference was significant(P<0.05).... |
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| Keywords: | NSCLC Vasculogenic mimicry VEGF Prognosis |
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