| 天然产物5,6,7,3′,4′-五甲氧基异黄酮的合成(英文) |
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| 引用本文： | 任宛莉,陈睿,金叶,张韬,李洪启. 天然产物5,6,7,3′,4′-五甲氧基异黄酮的合成(英文)[J]. 天然产物研究与开发, 2010, 22(6) |
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| 作者姓名： | 任宛莉 陈睿 金叶 张韬 李洪启 |
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| 摘 要： | 以3,4-二甲氧基苯乙酸和3,4,5-三甲氧基苯酚为原料,通过一条包括酯化反应、Fries重排、以及Vilsmeier-Haack反应等5步反应的路线合成了天然产物5,6,7,3′,4′-五甲氧基异黄酮。根据3,4,5-三甲氧基苯酚计算目标产物的总收率为76%,利用NMR及元素分析确证了化合物的结构。
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| 关 键 词： | 5,6,7,3',4'-五甲氧基异黄酮 3,4,5-三甲氧基苯酚 Fries重排 Vilsmeier-Haack反应 合成 |
Synthesis of the Natural Product 5,6,7,3',4'-Pentamethoxyisoflavone |
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| REN Wan-li,CHEN Rui,JIN Ye,ZHANG Tao,LI Hong-qi. Synthesis of the Natural Product 5,6,7,3',4'-Pentamethoxyisoflavone[J]. Natural Product Research and Development, 2010, 22(6) |
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| Authors: | REN Wan-li CHEN Rui JIN Ye ZHANG Tao LI Hong-qi |
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| Abstract: | The natural product 5,6,7,3',4'-pentamethoxyisoflavone was synthesized by a 5-step synthetic protocol inclu-ding esterification, Fries transformation, and Vilsmeier-Haack reaction with 3, 4-dimethoxyphenylacetic acid and 3,4,5-trimethoxyphenol as the starting materials. The overall yield of the target compound was 76% based on 3,4,5-trime-thoxyphenol. The structure of the natural isoflavone 5,6,7,3',4'-pentamethoxyisoflavone was confirmed by NMR and el-emental analysis. |
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| Keywords: | 5,6,7,3',4'-pentamethoxyisoflavone 3,4,5-trimethoxyphenol fries transformation Vilsmeier-Haack reaction synthesis |
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