Antigenic polysaccharides of bacteria: 42. Structures of O-polysaccharides from two Shigella dysenteriae type 8 strains |
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| Authors: | A V Perepelov S N Senchenkova A S Shashkov Yu A Knirel B Lu L Feng L Wang |
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| Institution: | (1) Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Leninskii pr. 47, Moscow, 119991, Russia;(2) TEDA School of Biological Sciences and Biotechnology, Nankai University, 23 HongDa st., TEDA, Tian-jin, 300457, China;(3) Tian-jin Key Laboratory for Microbial Functional Genomics, TEDA College, Nankai University, 23 HongDa str., TEDA, Tian-jin, 300457, China |
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| Abstract: | The structure of the O-polysaccharide (O-antigen) from Shigella dysenteriae type 8 bacteria (strain 599) was corrected using modern NMR techniques (structure 1). The revisions concerned the position of the Glc residue (in the main, but not the side chain), the site of its substitution, and the configuration of the O-glycoside linkage of the GlcNAc residue. The S. dysenteriae type 8 bacterium (strain G1221), the second investigated representative, was found to produce another structural variant of the O-polysaccharide. It contains GlcNAc instead of the Glc residue in the main chain (structure 2). This data may lead to approval of division of S. dysenteriae type 8 into two subtypes:  | |
| Keywords: | NMR spectroscopy O-antigen Shigella dysenteriae structure of the bacterial polysaccharide |
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