Phosphoribosyl pyrophosphate synthetase activity affects growth and riboflavin production in <Emphasis Type="Italic">Ashbya gossypii</Emphasis> |
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| Authors: | Alberto Jiménez María A Santos José L Revuelta |
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| Institution: | 1.Instituto de Microbiología Bioquímica and Departamento de Microbiología y Genética,CSIC/Universidad de Salamanca, Campus Miguel de Unamuno,Salamanca,Spain |
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| Abstract: | Background Phosphoribosyl pyrophosphate (PRPP) is a central compound for cellular metabolism and may be considered as a link between
carbon and nitrogen metabolism. PRPP is directly involved in the de novo and salvage biosynthesis of GTP, which is the immediate precursor of riboflavin. The industrial production of this vitamin using the
fungus Ashbya gossypii is an important biotechnological process that is strongly influenced by substrate availability. |
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