Small protein-mediated quorum sensing in a Gram-negative bacterium |
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Authors: | Han Sang-Wook Sriariyanun Malinee Lee Sang-Won Sharma Manoj Bahar Ofir Bower Zachary Ronald Pamela C |
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Institution: | Department of Plant Pathology and the Genome Center, University of California Davis, Davis, California, United States of America. |
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Abstract: | The rice XA21 pattern recognition receptor binds a type I secreted sulfated peptide, called axYS22, derived from the Ax21 (activator of XA21-mediated immunity) protein. The conservation of Ax21 in all sequenced Xanthomonas spp. and closely related genera suggests that Ax21 serves a key biological function. Here we show that the predicted N-terminal sequence of Ax21 is cleaved prior to secretion outside the cell and that mature Ax21 serves as a quorum sensing (QS) factor in Xanthomonas oryzae pv. oryzae. Ax21-mediated QS controls motility, biofilm formation and virulence. We provide genetic evidence that the Xoo RaxH histidine kinase serves as the bacterial receptor for Ax21. This work establishes a critical role for small protein-mediated QS in a Gram-negative bacterium. |
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