Synthesis and antimicrobial studies of novel 1-benzhydryl-piperazine sulfonamide and carboxamide derivatives |
| |
| Authors: | Kumar C S Ananda Vinaya K Chandra J Narendra Sharath Thimmegowda N R Prasad S B Benaka Sadashiva C T Rangappa K S |
| |
| Institution: | Department of Studies in Chemistry, University of Mysore, Mysore, India. |
| |
| Abstract: | A series of novel substituted 1-benzhydryl-piperazine sulfonamide 8(a-f) and benzamides 9(a-h) were synthesized and their antimicrobial activities evaluated in vitro by paper disc diffusion and micro dilution method against standard strains of Gram-positive (Staphylococcus aureus ATCC 25953, Staphylococcus epidermis 25212, Bacillus cereus 11778, Bacillus substilis 6051) and Gram-negative (Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 2853, Proteus vulgaris ATCC 2853 and Salmonella typhi ATCC 9484) bacteria. Among the synthesized new compounds 8d, 8e, 9c, 9e, 9f and 9 h showed potent antimicrobial activities compared to the standard drug streptomycin. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
