Developmental expression and differentiation-related neuron-specific splicing of <Emphasis Type=Italic>metastasis suppressor 1</Emphasis>(Mtss1) in normal and transformed cerebellar cells期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Developmental expression and differentiation-related neuron-specific splicing of metastasis suppressor 1(Mtss1) in normal and transformed cerebellar cells

Authors:	Alexander Glassmann Sabine Molly Lachezar Surchev Tommy A Nazwar Martin Holst Wolfgang Hartmann Stephan L Baader John Oberdick Torsten Pietsch Karl Schilling

Affiliation:	1.Anatomisches Institut,Anatomie & Zellbiologie, University of Bonn,Bonn,Germany;2.Institut für Neuropathologie,University of Bonn,Bonn,Germany;3.Institut für Anatomie,University of Jena,Jena,Germany;4.Center for Molecular Neurobiology, Department of Neuroscience,The Ohio State University,Columbus,USA;5.Department of Anatomy, Histology and Embryology,Medical University Sofia,Sofia,Bulgaria

Abstract:	Background Mtss1 encodes an actin-binding protein, dysregulated in a variety of tumors, that interacts with sonic hedgehog/Gli signaling in epidermal cells. Given the prime importance of this pathway for cerebellar development and tumorigenesis, we assessed expression of Mtss1 in the developing murine cerebellum and human medulloblastoma specimens.

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