The association between male infertility and sperm disomy: Evidence for variation in disomy levels among individuals and a correlation between particular semen parameters and disomy of specific chromosome pairs期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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The association between male infertility and sperm disomy: Evidence for variation in disomy levels among individuals and a correlation between particular semen parameters and disomy of specific chromosome pairs

Authors:	Helen?G?Tempest Sheryl?T?Homa Maria?Dalakiouridou Dimitra?Christopikou David?Wright Xiao?P?Zhai Email author" target="_blank">Darren?K?Griffin Email author

Institution:	(1) Cell and Chromosome Biology Group, Department of Biological Sciences, Brunel University, Uxbridge, UK;(2) 112 Harley Street, London, UK;(3) Medicines Control Agency, Market Towers, 1 Nine Elms Lane, London, UK;(4) Department of Biosciences, University of Kent, CT2 7NZ Canterbury, UK

Abstract:	Background The association between infertility and sperm disomy is well documented. Results vary but most report that men with severely compromised semen parameters have a significantly elevated proportion of disomic sperm. The relationship between individual semen parameters and segregation of specific chromosome pairs is however less well reported as is the variation of disomy levels in individual men.

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