| 胞外ATP在呼吸道中的作用 |
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| 引用本文： | Guo HM,Luo YL,Zhou WL. 胞外ATP在呼吸道中的作用[J]. 生理科学进展, 2010, 41(3): 189-192 |
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| 作者姓名： | Guo HM Luo YL Zhou WL |
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| 作者单位： | 中山大学生命科学学院,广州,510275;广东教育学院生物学系,广州,510303;中山大学生命科学学院,广州,510275 |
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| 基金项目： | 国家自然科学基金,国家重点基础研究发展计划(973计划)基金(2009CB522102)资助课题 |
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| 摘 要： | ATP不但是各种细胞的能量来源,而且更是一种自分泌或旁分泌的胞外信使,参与细胞一系列的生物学效应。ATP从呼吸道上皮细胞中释放,在调节呼吸道表面液体量的平衡、黏膜纤毛清除能力和呼吸道防御功能方面起重要作用,并参与呼吸道疾病及炎症的发生。本文对ATP从呼吸道上皮释放的途径,ATP调节呼吸道上皮离子转运的机制,ATP对呼吸道平滑肌的双重调节作用,以及ATP参与呼吸道疾病和炎症的发生机制等方面予以综述。
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| 关 键 词： | ATP 呼吸道 离子转运 黏膜纤毛清除 炎症反应 |
The role of extracellular ATP in the airway |
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| Guo Hong-Mei,Luo Yu-Li,Zhou Wen-Liang. The role of extracellular ATP in the airway[J]. Progress in Physiological Sciences, 2010, 41(3): 189-192 |
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| Authors: | Guo Hong-Mei Luo Yu-Li Zhou Wen-Liang |
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| Affiliation: | School of Life Science, SUN Yat-sen University, Guangzhou 510275, China. |
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| Abstract: | ATP serves not only as an energy source for all cell types but as an extracellular messenger for autocrine and paracrine signaling involving in a versatile role in modulating various cellular functions. This review summarizes the efflux pathways of ATP released from airway epithelial cells, the signal pathways through which ATP induces ion transport by the epithelia of airway, as well as its epithelium-dependent modulation of smooth muscle contraction of airway and the mechanism underlying in airway diseases. |
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| Keywords: | ATP |
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