薛氏4号方联合苯磺酸氨氯地平片治疗湿热侵络型高血压的疗效及对血脂和血液流变学的影响

摘要 目的：观察湿热侵络型高血压患者经苯磺酸氨氯地平片联合薛氏4号方治疗后的疗效及其对血脂和血液流变学的影响。方法：采用随机数字表法将2020年1月~2022年12月期间石家庄市中医院收治的120例湿热侵络型高血压患者分为对照组（n=60，苯磺酸氨氯地平片治疗）及联合组（n=60，对照组基础上接受薛氏4号方治疗）。观察两组治疗4周后的临床疗效，对比两组治疗前、治疗4周后的血压、中医证候积分、血脂和血液流变学情况。结果：联合组的临床总有效率高于对照组（P<0.05）。联合组治疗4周后收缩压（SBP）、舒张压（DBP）低于对照组（P<0.05）。联合组治疗4周后眩晕、头痛、口渴少饮、肢体困重、失眠、心悸、胸闷、肢体麻木中医证候积分低于对照组（P<0.05）。联合组治疗4周后甘油三酯（TG）、总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）低于对照组，高密度脂蛋白胆固醇（HDL-C）高于对照组（P<0.05）。联合组治疗4周后红细胞聚集指数、血小板最大聚集率、全血高切黏度、全血低切黏度低于对照组（P<0.05）。结论：薛氏4号方联合苯磺酸氨氯地平片治疗湿热侵络型高血压，可提高临床疗效，降低血压，降低中医证候积分，改善血脂和血液流变学。

Efficacy of Xueshi No.4 Recipe Combined with Amlodipine Besylate Tablet in the Treatment of Hypertension of Damp Heat Invading Collaterals and Its Effect on Blood Lipids and Hemorheology

ABSTRACT Objective: To observe the curative effect of Amlodipine besylate tablets combined with Xueshi No.4 recipe and its effect on blood lipids and Hemorheology in patients with hypertension of dampness heat invading collaterals. Methods: 120 patients with damp heat collateral invasion hypertension admitted to Shijiazhuang Traditional Chinese Medicine Hospital from January 2020 to December 2022 were divided into the control group (n=60, treated with Amlodipine besylate tablets) and the combined group (n=60, treated with Xueshi No.4 recipe on the basis of the control group) by random number table. The clinical efficacy in two groups 4 weeks after treatment was observed, the blood pressure, traditional Chinese medicine syndrome scores, blood lipids and hemorheology before treatment and 4 weeks after treatment were compared between two groups. Results: The clinical total effective rate in combined group was higher than that in control group(P<0.05). Systolic blood pressure (SBP) and diastolic blood pressure (DBP) in combined group at 4 weeks after treatment were lower than those in control group(P<0.05). The traditional Chinese medicine syndrome scores of vertigo, headache, thirst and lack of drinking, limb fatigue, insomnia, palpitations, chest tightness,and limb numbness in combined group at 4 weeks after treatment were lower than those in control group(P<0.05). The triglyceride (TG), total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) in combined group at 4 weeks after treatment were lower than those in control group, while high-density lipoprotein cholesterol (HDL-C) in combined group at 4 weeks after treatment was higher than those in control group (P<0.05). The erythrocyte aggregation index, maximum platelet aggregation rate, whole blood high shear viscosity, and whole blood low shear viscosity in combined group at 4 weeks after treatment were lower than those in control group(P<0.05). Conclusion: Xueshi No.4 recipe combined with amlodipine besylate tablet in the treatment of hypertension of damp heat invading collaterals, which can improve clinical efficacy, reduce blood pressure, reduce traditional Chinese medicine syndrome scores, and improve blood lipids and hemorheology.