Pregabalin and gabapentin inhibit substance P-induced NF-kappaB activation in neuroblastoma and glioma cells |
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Authors: | Park Seyeon Ahn Eun Sook Han Dong Woo Lee Jong Hwa Min Kyung Tae Kim Hyunkyung Hong Yong-Woo |
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Institution: | Dongduk Women's University, Department of Applied Chemistry, Seoul, Korea. sypark21@dongduk.ac.kr |
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Abstract: | Pregabalin and gabapentin are lipophilic amino acid derivatives of gamma-amino butyric acid that show anticonvulsant and analgesic activity against neuropathic pain. In this study, we investigated their actions on substance P-induced NF-kappaB activation in human neuroblastoma and rat glioma cells. Pregabalin and gabapentin decreased substance P-induced NF-kappaB activation in these cells. These drugs also inhibited NF-kappaB activation in rat spinal dorsal root ganglia cells pre-treated in vitro with substance P. These results suggest a previously undefined role of pregabalin and gabapentin in the regulation of inflammation-related intracellular signaling in both neuronal and glial cells. |
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Keywords: | pregabalin gabapentin substance P NF‐κB neuroblastoma glioma |
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