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Generation and characterization of human insulin-releasing cell lines |
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| Authors: | Leticia Labriola Maria G Peters Karin Krogh Iván Stigliano Letícia F Terra Cecilia Buchanan Marcel CC Machado Elisa Bal de Kier Joffé Lydia Puricelli Mari C Sogayar |
| Affiliation: | 1. Nucleo de Terapia Celular e Molecular (NUCEL), Universidade de S?o Paulo, S?o Paulo, SP, Brazil 2. "Angel. H. Roffo" Institute of Oncology, Research Area, Universidad de Buenos Aires, Buenos Aires, Argentina 3. Instituto de Química,USP, S?o Paulo, Brasil 4. Cirurgia, Faculdade de Medicina, USP, S?o Paulo, Brasil |
| Abstract: | BackgroundThe in vitro culture of insulinomas provides an attractive tool to study cell proliferation and insulin synthesis and secretion. However, only a few human beta cell lines have been described, with long-term passage resulting in loss of insulin secretion. Therefore, we set out to establish and characterize human insulin-releasing cell lines. |
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