Age-related changes in the functioning of the mitochondrial potassium-transporting system |
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| Authors: | M. I. Shigaeva E. N. Gritsenko S. V. Murzaeva O. S. Gorbacheva E. Yu. Talanov G. D. Mironova |
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| Affiliation: | 1.Institute of Theoretical and Experimental Biophysics,Russian Academy of Sciences,Pushchino, Moscow Region,Russia;2.Pushchino State University,Pushchino, Moscow Region,Russia |
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| Abstract: | Changes in the rate of respiration and functioning of the ATP-dependent potassium channel in liver and heart mitochondria of one-, three-, eight-, and 24-month-old Wistar male rats have been investigated. It was shown that the activity of the channel in the mitochondria of both tissues in 24-month-old animals decreases more than three times, and the content of potassium, 1.5–2 times compared with young one-month-old rats. The changes occur against the background of age-related decrease of energy supply in mitochondria, the respiratory complex-I undergoing the greatest changes upon aging. The decrease of channel activity may be the result of changes in channel sensitivity to modulators and a decrease in the expression of mitochondrial K+-transporting channel-protein with a molecular mass of 5.5 kDa upon aging found in this work. As a result, the functioning of not only the mitoKATP but also the whole mitochondrial potassium cycle is impaired. |
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