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3-Substituted gem-cyclohexane sulfone based gamma-secretase inhibitors for Alzheimer's disease: conformational analysis and biological activity |
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| Authors: | Jelley Richard A Elliott Jason Gibson Karl R Harrison Timothy Beher Dirk Clarke Earl E Lewis Huw D Shearman Mark Wrigley Jonathan D J |
| Institution: | Department of Medicinal Chemistry, Merck Sharp and Dohme Research Laboratories, The Neuroscience Research Centre, Terlings Park, Eastwick Road, Harlow, Essex CM20 2QR, UK. richard_jelly@yahoo.co.uk |
| Abstract: | Previously, chemistry effort on the gem-cyclohexane series of gamma-secretase inhibitors has focused on the 4-position of the cyclohexane ring. Recently chemistry has been directed towards the 3-position and substitution here has also provided compounds with high gamma-secretase activity. |
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