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Relationship between clinical signs and postmortem test status in cattle experimentally infected with the bovine spongiform encephalopathy agent |
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| Authors: | Timm Konold A Robin Sayers Amanda Sach Gemma E Bone Steven van Winden Gerald AH Wells Marion M Simmons Michael J Stack Angus Wear Steve AC Hawkins |
| Affiliation: | 1.Veterinary Laboratories Agency Weybridge,Host Pathology and Susceptibility Department,New Haw, Addlestone,UK;2.Veterinary Laboratories Agency Weybridge,Centre for Epidemiology and Risk Analysis,New Haw, Addlestone,UK;3.ADAS Drayton,Stratford upon Avon,UK;4.Royal Veterinary College,Department of Veterinary Clinical Sciences,North Mymms, Hatfield,UK;5.Veterinary Laboratories Agency Newcastle,Laboratory Services,Longbenton, Newcastle-upon-Tyne,UK |
| Abstract: | BackgroundVarious clinical protocols have been developed to aid in the clinical diagnosis of classical bovine spongiform encephalopathy (BSE), which is confirmed by postmortem examinations based on vacuolation and accumulation of disease-associated prion protein (PrPd) in the brain. The present study investigated the occurrence and progression of sixty selected clinical signs and behaviour combinations in 513 experimentally exposed cattle subsequently categorised postmortem as confirmed or unconfirmed BSE cases. Appropriate undosed or saline inoculated controls were examined similarly and the data analysed to explore the possible occurrence of BSE-specific clinical expression in animals unconfirmed by postmortem examinations. |
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