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Decreased expression of ATP6V1H in type 2 diabetes: a pilot report on the diabetes risk study in Mexican Americans |
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| Authors: | Molina Melanie F Qu Hui-Qi Rentfro Anne R Nair Saraswathy Lu Yang Hanis Craig L McCormick Joseph B Fisher-Hoch Susan P |
| Affiliation: | aDivision of Epidemiology, Human Genetics and Environmental Sciences, Brownsville Regional Campus, The University of Texas School of Public Health, Brownsville, TX, USA;bCollege of Nursing, The University of Texas at Brownsville, Brownsville, TX, USA;cDepartment of Biological Sciences and Center of Biomedical Studies, University of Texas at Brownsville, Brownsville, TX, USA;dUniversity of Texas Health Science Center, School of Public Health, Human Genetics Center, Houston, TX, USA |
| Abstract: | ObjectivePrevious studies in mice and humans observed down-regulation of the gene expression of ATP6V1H associated with type 2 diabetes. This study identified prospectively changes in ATP6V1H expression before and after overt diabetes.MethodsExpression of ATP6V1H in peripheral blood was compared pre and post development of diabetes in nine individuals.ResultsConsiderable variation of ATP6V1H mRNA levels was observed between different individuals. However, within each individual the decrease in expression of ATP6V1H with the development of diabetes was highly statistically significant.ConclusionsATP6V1H may represent a critical molecular mechanism involved in the development of type 2 diabetes and its compilations through its important regulatory effect on vacuolar-ATPase activity. |
| Keywords: | ATP6V1H Diabetic complications Longitudinal study Type 2 diabetes Vacuolar ATPase |
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