Inflammatory peptides derived from adipose tissue |
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Authors: | Eric?Rudin Email author" target="_blank">Nir?BarzilaiEmail author |
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Institution: | (1) Department of Medicine, Institute for Aging Research, Diabetes Research and Training Center, Albert Einstein College of Medicine, Bronx, New York, USA |
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Abstract: | The low-grade inflammation seen with aging is noted particularly in subjects with the metabolic syndrome of aging. Insulin
resistance, obesity/abdominal obesity, and risks for many age-related diseases characterize this common syndrome. It is becoming
clear that this increased adipose tissue is not simply a reservoir for excess nutrients, but rather an active and dynamic
organ capable of expressing several cytokines and other fat-derived peptides (FDP). Some, but not all, FDP may have a role
in development of the metabolic syndrome but there is no evidence that these FDP are causing inflammation directly. We suggest
that high levels of inflammatory peptides are markers for obesity/abdominal obesity seen with aging, but some may not necessarily
have a causative role in the development of inflammation. |
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Keywords: | |
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