| 细菌Na+/H+逆向转运蛋白的研究进展 |
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| 引用本文： | 徐宁,程海娇,刘清岱,刘君,马延和.细菌Na+/H+逆向转运蛋白的研究进展[J].微生物学通报,2015,42(10):2002-2011. |
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| 作者姓名： | 徐宁 程海娇 刘清岱 刘君 马延和 |
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| 作者单位： | 1. 中国科学院天津工业生物技术研究所 天津 300308,2. 天津科技大学 食品工程与生物技术学院 天津 300457,2. 天津科技大学 食品工程与生物技术学院 天津 300457,1. 中国科学院天津工业生物技术研究所 天津 300308,1. 中国科学院天津工业生物技术研究所 天津 300308 |
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| 基金项目： | 中国科学院“百人计划”项目；国家自然科学基金项目(No. 31500044) |
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| 摘 要： | Na+/H+逆向转运蛋白在维持细胞内pH稳态、Na+离子动态平衡和调控细胞体积方面发挥着重要作用。目前，细菌中许多参与高盐或高碱性环境压力应答的Na+/H+逆向转运蛋白得到了鉴定和功能阐释。继续挖掘高效的Na+/H+逆向转运蛋白，深入探究Na+/H+逆向转运蛋白的分子机理，将为工业菌株或农作物的改良提供新的研究思路。本文以4种模式菌株为例，简要概述细菌Na+/H+逆向转运蛋白的种类和特征，同时对其结构和功能等方面也进行探讨。
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| 关 键 词： | Na+/H+逆向转运蛋白，细菌，种类，功能 |
Research progress of the Na+/H+ antiporters in bacteria |
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| XU Ning,CHENG Hai-Jiao,LIU Qing-Dai,LIU Jun and MA Yan-He.Research progress of the Na+/H+ antiporters in bacteria[J].Microbiology,2015,42(10):2002-2011. |
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| Authors: | XU Ning CHENG Hai-Jiao LIU Qing-Dai LIU Jun and MA Yan-He |
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| Institution: | 1. Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, China,2. College of Food Engineering and Biotechnology, Tianjin University of Science and Technology, Tianjin 300457, China,2. College of Food Engineering and Biotechnology, Tianjin University of Science and Technology, Tianjin 300457, China,1. Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, China and 1. Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, China |
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| Abstract: | The Na+/H+ antiporters play a primary role in the maintenance of intracellular pH homeostasis and dynamic balance of cellular Na+, and in the regulation of cell volume. Currently, many Na+/H+ antiporter genes involved in the resistance to high salt and alkaline pH stresses have been identified and functionally characterized in various bacteria. The prospection for novel Na+/H+ antiporters from unexplored habitats, in conjunction with our understanding of the mechanisms responsible for Na+/H+ antiport activity, will provide new insights into industrial and agricultural biotechnology. In this review, we chose four physiologically distinct bacteria as examples, and summarized the classification, structure and function of bacterial Na+/H+ antiporters. |
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| Keywords: | Na+/H+ antiporters bacteria classification function |
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