| miR-34家族——-肿瘤抑制蛋白p53高度相关microRNA |
| |
| 引用本文： | 娄文加,陈青,刘立,钱程.miR-34家族——-肿瘤抑制蛋白p53高度相关microRNA[J].遗传,2010,32(5):423-430. |
| |
| 作者姓名： | 娄文加 陈青 刘立 钱程 |
| |
| 作者单位： | 浙江理工大学生命科学学院,新元医学与生物技术研究所,杭州,310018 |
| |
| 基金项目： | 国家自然科学基金项目(编号: 30872984) 和浙江省重中之重学科开放基金项目(编号: SWYX0816)资助 |
| |
| 摘 要： | 若干微小RNA(microRNA, miRNA)与肿瘤抑制蛋白p53高度相关, 其中miR-34家族最具代表性。一方面p53可通过对miR-34家族的调控实现对多个原癌基因如Bcl-2、c-myc以及细胞因子如cyclinE2、cyclinD1和c-Met的抑制, 进而发挥抑癌作用; 另一方面miR-34家族也可以通过抑制沉默信息调节子SIRTI来进一步增强p53的活性。p53与miR-34家族之间形成的正反馈调节网络对抑制肿瘤的发生发展及恶化均起着重要的作用。文章对p53高度相关的miR-34家族在肿瘤发生发展及治疗的最新进展作一论述。
|
| 关 键 词： | miR-34家族 p53 反馈调节 |
| 收稿时间： | 2009-09-24 |
| 修稿时间： | 2009-11-25 |
miR-34s——a tumor suppression protein p53 highly related microRNA |
| |
| LOU Wen-Jia,CHEN Qing,LIU Li,QIAN Cheng Xinyuan Institute of Medicine , Biotechnology,College of Life Science,Zhejiang Sci-Tech University,Hangzhou ,China.miR-34s——a tumor suppression protein p53 highly related microRNA[J].Hereditas,2010,32(5):423-430. |
| |
| Authors: | LOU Wen-Jia CHEN Qing LIU Li QIAN Cheng Xinyuan Institute of Medicine Biotechnology College of Life Science Zhejiang Sci-Tech University Hangzhou China |
| |
| Institution: | Xinyuan Institute of Medicine and Biotechnology, College of Life Science, Zhejiang Sci-Tech University, Hangzhou 310018, China |
| |
| Abstract: | Several microRNAs, most representatively the miR-34, are highly related to tumor suppression protein p53. p53 exerts its tumor suppression function known as inhibiting multiple-oncogenes, such as Bcl-2, c-myc and cell cytokines such as cyclinE2, cyclinD1 and c-Met through the regulation of miR-34. On the other hand, miR-34 enhances the activities of p53 by inhibiting silence information regulator I (SIRTI). The positive feedback regulatory network based on p53 and miR-34 families play an important role in suppression of oncogenesis and deterioration. This paper summarizes the latest advances of p53 highly related miR-34 families in oncogenesis and treatment. |
| |
| Keywords: | p53 |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
| 点击此处可从《遗传》浏览原始摘要信息 |
| 点击此处可从《遗传》下载免费的PDF全文 |
|
