Saccharin inhibits guanylate cyclase activity: possible relationship to carcinogenesis. |
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| Authors: | D L Vesely G S Levey |
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| Affiliation: | Department of Medicine University of Miami School of Medicine Miami, Florida 33152 USA |
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| Abstract: | Saccharin (2,3-dihydro-3-oxobenzisosulfonazole) decreased the activity of rat guanylate cyclase (E.C. 4.6.1.2) 60 to 75 percent in urinary bladder. Inhibition was also seen in kidney, liver, stomach, and lung. Since a number of mutagenic chemical carcinogens decrease guanylate cyclase activity, this effect of saccharin may account for its mutagenicity. |
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