Correlation between maternal plasma homocysteine and zinc levels in preeclamptic women |
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Authors: | Mehmet Harma Muge Harma Abdurrahim Kocyigit |
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Institution: | (1) Department of Gynecology and Obstetrics, University of Harran, Faculty of Medicine, Sanliurfa, Turkey;(2) Department of Biochemistry, University of Harran, Faculty of Medicine, Sanliurfa, Turkey |
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Abstract: | Women with preeclampsia have been shown to have elevated blood levels of the metabolite homocysteine, and alterations in blood
levels of zinc and copper have also been reported. This study measured plasma levels of zinc, copper, and homocysteine in
women with preeclampsia and in women with healthy, normotensive pregnancies.
For the patients with preeclampsia compared with controls, significantly higher mean plasma levels were found of homocysteine
(16.39 vs 9.45 nmol/mL; p≤0.001), zinc (15.53 vs 11.93 μg/g protein; p < 0.05), and copper (47.90 vs 31.60 μg/g protein; p=0.001). The ratio of plasma Cu/Zn levels tended to be higher in preeclamptic women and could be taken as an index of inflammatory
reaction, but the difference was not significant. Homocysteine concentrations correlated positively with plasma zinc concentrations
in women with preeclampsia (r=0.588, p=0.003) but not in women with healthy pregnancies. No correlations were observed between plasma levels of homocysteine and
copper.
Thus, the present study found evidence that preeclampsia might be associated with hyperhomocysteinemia and elevated blood
levels of zinc and copper. Furthermore, elevated blood levels of zinc were significantly associated with hyperhomocysteinemia
in preeclampsia. More studies are warranted to investigate further any relationship between altered homocysteine metabolism
and levels of zinc and copper in preeclampsia. |
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Keywords: | Copper zinc homocysteine plasma preeclampsia |
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