Effects of low-molecular-weight aluminum complexes on brain tissue calcium homeostasis |
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Authors: | Leopold J Anghileri Pierre Thouvenot Alain Bertrand |
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Institution: | (1) Biophysics Laboratory, Medicine Faculty University of Nancy, 54505 Vandoeuvre lès Nancy, France;(2) Nuclear Medicine Service, University of Nancy Medical Center, Nancy, France |
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Abstract: | The in vitro effects of low-molecular-weight aluminum complexes (citrate, lactate, and ATP complex) on the Ca2+ uptake and aluminum-induced lipid peroxidation of brain tissue show that the modification of the calcium homeostasis is determined
by the nature of the ligand and that there is no correlation between the aluminum-induced lipid peroxidation and the Ca2+ uptake. The same characteristics have been shown by a similar study performed with Ehrlich carcinoma cells. The electrophoretic
analyses of the aluminum lactate-albumin and aluminum lactate-ATP interactions indicate an aluminum transfer from the lactate
to the albumin and ATP ligands. The increased Ca2+ uptake when ATP is present in the incubation medium with aluminum citrate and aluminum lactate corroborates the suggested
mediator role of ATP in cellular calcium homeostasis modification induced by iron. |
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Keywords: | Brain calcium homeostasis low-molecular-weight aluminum complexes |
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