Yak lactate dehydgogenase A4: purification, properties, and cDNA cloning |
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| Authors: | Zheng Yucai Si Xiaohui He Qinghua Jin Suyu Hong Jian |
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| Affiliation: | College of Life Science and Technology, Southwest University for Nationalities, Chengdu, PR China. yucaizheng01@gmail.com |
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| Abstract: | Lactate dehydrogenase A4 (LDH-A4) was purified for yak skeletal muscle. Michaelis constant (Km) analysis showed that yak LDH-A4 for pyruvate was significantly higher than that of cattle. cDNA cloning of LDH-A revealed two amino acid substitutions between yak and cattle. We suggest that the higher Km of yak LDH-A4 might be a result of molecular adaptation to a hypoxic environment. |
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