ECM和YAP/TAZ在决定细胞命运的过程中的作用机制

近年来,有研究表表明从细胞微环境中转化而来的机械信号可以调控细胞形状和影响细胞的命运。然而,这些机械信号转化成调节细胞生物过程的信号的机制仍然不是十分清楚。最新研究已阐明细胞可通过来自细胞外基质(extracellular matrix,ECM)的机械信号和细胞行为调控之间的相互作用来募集Hippo信号通路中的核心组件YAP/TAZ的作用机制。此外,研究发现在Wnt和Hippo信号之间的串扰是调节细胞命运的核心。这些机制可以解释力学微环境的信号是如何调节细胞行为和决定细胞命运的。本文重点对ECM和YAP/TAZ在决定细胞命运的过程中的作用机制展开系统综述。

Role of EMC and YAP/TAZ in Cell Fate Determination

In recent years, studies have shown that the mechanical signals transduced from cellular microenvironment can regulate cell shape and affect cell fate determination. However, how these mechanical signals are transduced to regulate biological processes of cells has remained elusive. Recent studies had elucidated a mechanism through which the interactions between mechanical signals from extracellular matrix and cell behavior regulation converged on the function of core components YAP/TAZ in Hippo signaling pathway,. Moreover, several very recent studies have found a new crosstalk between Wnt and Hippo signaling in the regulation of cell fate determination. Those mechanism may explain how mechanical signals from microenvironment can regulate cell behavior and determine cell fate. In this paper, we systematic reviewing the mechanismof ECMand YAP/TAZ in cell fate determination process.