Corpus luteum susceptibility to prostaglandin F2α (PGF2α) luteolysis in hysterectomized prepuberal and mature gilts |
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Authors: | Tony A Puglisi George B Rampacek Robert R Kraeling Terry E Kiser |
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Institution: | 1. Department of Animal and Dairy Science, University of Georgia, USA;2. Richard B. Russell Research Center, SEA, USDA Athens, Georgia 30602 USA |
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Abstract: | The susceptibility of induced corpora lutea (CL) of prepuberal gilts and spontaneously formed CL of mature gilts to prostaglandin F2α (PGF2α) luteolysis was studied. Prepuberal gilts (120 to 130 days of age) were induced to ovulate with Pregnant Mare Serum Gonadotropin and Human Chorionic Gonadotropin (HCG). The day following HCG was designated as Day 0. Mature gilts which had displayed two or more estrous cycles of 18 to 22 days were used (onset of estrus = Day 0). Gilts were laparotomized on Day 6 to 9, their CL marked with sterile charcoal and totally hysterectomized. On Day 20, gilts were injected IM with either distilled water (DW), 2.5 mg PGF2α or 5.0 mg PGF2α. An additional group of prepuberal gilts was injected with 1.25 mg PGF2α, a dose of PGF2α equivalent, on a per kilogram body weight basis, to the 2.5 mg PGF2α dose given to the mature gilts. The percentages of luteal regression on Day 27 to 30 for mature and prepuberal gilts given DW, 2.5 mg PGF2α and 5.0 mg PGF2α were 0.0 vs 4.4, 43.5 vs 96.8 and 47.7 vs 91.6, respectively; the percentage of luteal regression for the prepuberal gilts given 1.25 mg PGF2α was 75.1. These results indicate that induced CL of the prepuberal gilt were more susceptible to PGF2α luteolysis than spontaneously formed CL of the mature gilt and that pregnancy failure in the prepuberal gilt could be due to increased susceptibility of induced CL to the natural luteolysin. |
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