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Novel cyanoguanidines with potent oral antitumour activity |
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| Authors: | Charlotte Schou Erik R Ottosen Hans Jørgen Petersen Fredrik Björkling Scilla Latini Pernille V Hjarnaa Erik Bramm Lise Binderup |
| Institution: | a Department of Chemistry, Leo Pharmaceutical Products, Industriparken 55, DK-2750, Ballerup, Denmark b Department of Biochemistry, Leo Pharmaceutical Products, Industriparken 55, DK-2750, Ballerup, Denmark c Department of Pharmacology, Leo Pharmaceutical Products, Industriparken 55, DK-2750, Ballerup, Denmark |
| Abstract: | 4-Pyridyl cyanoguanidines with hydrophobic aromatic side chains showed potent antiproliferative activity in the human breast and lung cancer cell lines MCF-7, NYH and H460. In vivo, treatment with N-(6-chlorophenoxyhexyl)-N′-cyano-N″-4-pyridylguanidine (18, 20 mg/kg/day po.), gave a complete remission of tumours in a model of NYH inoculated nude mice. |
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