Determination of tripamide and its metabolites in plasma,red blood cells and urine by high-performance liquid chromatography |
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| Authors: | T. Horie T. Ohno K. Kinoshita |
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| Affiliation: | Section of Drug Metabolism and Biopharmaceutics, Research and Development Division, Eisai Co., Ltd., Koishikawa 4, Bunkyo-ku, Tokyo Japan |
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| Abstract: | A procedure for the determination of tripamide and its hydroxylated metabolites in plasma, red blood cells and urine by reversed-phase high-performance liquid chromatography is described.The concentrations in red blood cells showed a monophasic decline and the half-life was 9.5 h. The concentration in red blood cells was markedly higher than that in plasma, showing that 95–98% of the drug is present in whole blood, after a dose of tripamide (90 mg) in man. The specificity and sensitivity of this procedure appear to be satisfactory for pharmacokinetic studies. |
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