Electrogenerated chemiluminescence of novel TiO2/CdS nanocomposites for sensitive assays of cancer cells |
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| Authors: | Tingyu Huang Guifen Jie |
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| Institution: | 1. Linyi University, Linyi 276000, Shandong, People’s Republic of China;2. Key Laboratory of Eco-chemical Engineering, Ministry of Education, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, People’s Republic of China |
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| Abstract: | A novel TiO2/CdS nanocomposite was prepared and used to fabricate an electrochemiluminescence (ECL) biosensor for the detection of cancer cells for the first time. The nanocomposite exhibited a strong cathodic ECL signal. Folic acid for targeting cell membranes was bound to a TiO2/CdS/3-aminopropyltriethoxysilane film, and specific recognition of folic acid to targeting cells was achieved, leading to a significant decrease in ECL intensity. The decrease in ECL signal was logarithmically related to the cell concentration in the range of 150–9600 cells mL-1. The ECL biosensor could provide a sensitive, selective, and convenient approach for early and accurate detection of cancer cells. |
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| Keywords: | TiO2/CdS nanocomposites Electrochemiluminescence biosensor |
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