Brief inactivation of c-Myc is not sufficient for sustained regression of c-Myc-induced tumours of pancreatic islets and skin epidermis |
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Authors: | Email author" target="_blank">Stella?PelengarisEmail author Sylvie?Abouna Linda?Cheung Vasiliki?Ifandi Sevasti?Zervou Michael?Khan |
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Institution: | (1) Department of Biological Sciences, Biomedical Research Institute, University of Warwick, Gibbet Hill Road, Coventry, CV4 7AL, UK |
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Abstract: | Background Tumour regression observed in many conditional mouse models following oncogene inactivation provides the impetus to develop,
and a platform to preclinically evaluate, novel therapeutics to inactivate specific oncogenes. Inactivating single oncogenes,
such as c-Myc, can reverse even advanced tumours. Intriguingly, transient c-Myc inactivation proved sufficient for sustained
osteosarcoma regression; the resulting osteocyte differentiation potentially explaining loss of c-Myc's oncogenic properties.
But would this apply to other tumours? |
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Keywords: | |
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