Antimycobacterial activity of two natural alkaloids,vasicine acetate and 2-acetyl benzylamine,isolated from Indian shrub <Emphasis Type="Italic">Adhatoda vasica</Emphasis> Ness. leaves |
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Authors: | S Ignacimuthu N Shanmugam |
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Institution: | (1) Centre of Advanced Study in Botany, Banaras Hindu University, Varanasi, 221005, India; |
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Abstract: | In folk medicine, Adhatoda vasica Ness. (Acanthaceae) is used to treat asthma and cough. The leaves of A.vasica were powdered and extracted with hexane, ethyl acetate and methanol. The hexane extract showed 97% reduction in colony-forming
units (CFU) at 100 μg/ml. The hexane extract was subjected to column chromatography. Two natural compounds, vasicine acetate
and 2-acetyl benzylamine, were isolated from it. They were bioassayed against Mycobacterium tuberculosis. The two compounds showed strong antimycobacterial activity. Vasicine acetate and 2-acetyl benzylamine isolated from hexane
extract of A.vasica leaves, significantly inhibited M. tuberculosis and one multi-drug-resistant (MDR) strain and one sensitive strain at 200 and 50 μg/ml, respectively. Our study demonstrated
that both the compounds, vasicine acetate and 2-acetyl benzylamine, could be evaluated further for developing a drug to control
M. tuberculosis. |
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Keywords: | |
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